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The present work aimed to investigation of influence molecular weight of chitosan, method of silver nanoparticles producing and immobilization, amount of cross-linking agent on antibacterial activity. Silver was incorporated in the matrix in two ways: 1 пїЅ by the recovery of silver ions from AgNO3 solution; 2 ? by addition to hydrogel the silver nanoparticles, obtained previously by microbiological synthesis. The molecular weight of chitosan shows strong influence on internal structure of matrices and on release ...

Nowadays the great attention is paid to the cultivation of different mammalian cells. They can be used, for example, for vaccines, monoclonal antibodies or viruses production, in regenerative medicine, diagnostics, for clinical trials and etc. The application of modelling and simulation tools for these purposes is very convenient and perspective in order to decrease the experiments and therefore the total cost for the investigations. In this article, the process cultivation of CHO cells is considered in hollow-fib...