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CRISPR-Cas adaptive immunity systems of prokaryotes have been identified in 42% of bacteria and 85% of archaea [1] and are actively used in genetic engineering. However, in nitrogen-fixing nodule bacteria required for agriculture, these systems are very poorly characterized. Therefore, in this study, we evaluated the diversity of CRISPR-Cas systems in the genomes of 39 isolates of alfalfa nodule bacteria Sinorhizobium meliloti recovered from soil samples from Kazakhstan and Turkmenistan, which belong to the Centra...

Currently, CRISPR/Cas systems are actively studied bacterial systems, due to the possibilitpossibility to apply them for targeted editing of eukaryotic genomes. CRISPR/Cas systems are belonged to adaptive immun immune system of bacteria and archaea acting against invading mobile genetic elements (MGEs: bacteriophages and integrative conjugative elements ). Curre Currently CRISPR/Cas systems were detected in genomes of 75% of known archaea and 36 % of bacteria strains . However, there are still quite less knowledge...