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We present herein a thoroughly study concerning synthesis, structure and fluorescent properties of two classes of pyrrolodiazine derivatives: pyrrolopyridazine respectively pyrrolophthalazine cycloadducts. The synthesis is straight and efficient, consisting in a 3+2 dipolar cycloaddition reaction of diazinium ylides to dipolarophiles with triple bound. The structure of compounds was proven by elemental and spectral analysis. The fluorescence studies reveal that the pyrrolodiazine compounds are intense blue emitter...

We present herein a thoroughly study regarding the synthesis, structure and biological activity of some hybrid diazine - polyphenols derivatives. The synthesis was performed under conventional thermal heating and microwave irradiation, by using a straight and efficient method: a N-alkylation reaction of diazine (pyridazine or phthalazine) with reactive halogenated derivatives. The structure of the hybrids was proven by elemental and spectral analysis. Under MW irradiation, the N-alkylation reaction of diazine have...

Discovery of new chemosensors for M2+ cations represent a continuously and challenging issue for researcher because of their potential applications in nano and micro technologies. Among the other metals, zinc is the second most abundant transition metal ion in human body and plays a crucial role in many biological and environmental processes. In this work we present the design, synthesis and characterization of a Zn2+ chemosensors and its coordination complexes based on podants with benzimidazole - pyridine skelet...

On the last few years, microwave and ultrasound irradiation has become a successful tool in modern medicinal and organic chemistry especially (but not only) because in many cases synthesis became ecologically friendly. As part of our ongoing efforts in the field of nitrogen heterocyclic derivatives, we present herein some core results obtained by our group in the field of N-alkylation and 3+2 cycloadditions reactions applied in the nitrogen heterocycles series, by using microwave and ultrasound irradiation. Compar...

Sulfonamides are appropriate ligands for the preparation of coordination compounds with biological activity, as they possess bactericidal, antiviral, antidiabetic, and diuretic properties and some sulfonamide compounds are under clinical evaluation for cancer treatment. Metal complexes provide highly versatile platforms for drug design. Considering the biological potential of the quinoline nucleus, but also of the sulfonamide scaffold (especially antimicrobial), as well as that of the quinoline- sulfonamide combin...

Spectrophotometric methods for total protein analysis are generally simple, rapid and sensitive. Such sensitive protein assays may have applications in forensic science, in the detection of protein contaminants in drugs and in a number of other applications of research interest. Biuret reaction with proteins and peptides is widely used in clinical and biological laboratories. In this work, instead of copper sulphate, sodium hydroxide and Seignette salt, we used insoluble copper phosphate, potassium or sodium hydro...