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Alzheimer?s disease (AD) is associated with conformational changes of amyloid-? peptides, which result in peptide oligomerization and fibril formation and, finally, in the appearance of senile plaques and extensive neuronal loss. However, the factors regulating the process of plaque-associated beta-amyloid peptide (A?) aggregation are only partly understood. Therefore, several ?-amyloid peptide fragments have been synthesized by SPPS according to Boc/Bzl strategy. Binding of metal ions to ?-amyloid peptides was st...

Alzheimer?s disease (AD) is associated with conformational changes of amyloid-? peptides, which result in peptide oligomerization and fibril formation and, finally, in the appearance of senile plaques and extensive neuronal loss. However, the factors regulating the process of plaque-associated beta-amyloid peptide (A?) aggregation are only partly understood. Therefore, several ?-amyloid peptide fragments have been synthesized by SPPS according to Boc/Bzl strategy. Binding of metal ions to ?-amyloid peptides was st...

Heavy and radioactive metal poisoning has become a problem of current interest as a result of environmental pollution on a global scale. Studies to test the noxious effect of radioactive metal ions on wheat germination and seedling growth showed that germination rate, shoot length, and fresh weights varied as a function of their concentration in the treatment solutions. We report here the effect of some radioactive and non-radioactive (stable) elements on the wheat seeds and seedlings (Triticum aestivum L.) in the...

During 2004, pluridisciplinary investigations have been devoted to the abiotic and biotic characteristics of the anthropized ecosystem developed in relation with the domestic litter hills at Tomesti, Iasi. Both abiotic (climate, soil, air) and biotic (talobyontes, chormobyontes, phytophagous invertebrata) parameters have been recorded. The results showed that the urban wastes deposit has a complex impact upon the environment: air pollution with odours and dust, soil pollution with heavy metals (Pb, Ni, Cr, Cd, Cu)...