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Erythromycin (E), a hydrophobic macrolide antibiotic, is prescribed for the treatment of acute bacterial infections, such as respiratory, urine, skin, and mouth infections. The main disadvantage of ER is its poor water solubility (2 mg/mL) that limits both formulation using hydrophilic bases and skin permeability. Cyclodextrins (CDs) are biocompatible cyclic oligomers of glucose, with a hydrophobic core and a hydrophilic exterior. CDs are used to improve the bioavailability of drugs by increasing their solubility ...