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Skin cancer is a disease with an increasing incidence due to its complex etiology and various forms of manifestation. The topical treatment can be a successful therapeutic approach in early diagnosed cutaneous neoplasm. The main drawback of the drugs currently in use is the low bioavailability caused by many pathophysiological and pharmaceutical factors. The aim of the present study was to develop new modifiedrelease topical products by encapsulating bexarotene into biocompatible silica matrices and by formulating...

Erythromycin (E), a hydrophobic macrolide antibiotic, is prescribed for the treatment of acute bacterial infections, such as respiratory, urine, skin, and mouth infections. The main disadvantage of ER is its poor water solubility (2 mg/mL) that limits both formulation using hydrophilic bases and skin permeability. Cyclodextrins (CDs) are biocompatible cyclic oligomers of glucose, with a hydrophobic core and a hydrophilic exterior. CDs are used to improve the bioavailability of drugs by increasing their solubility ...

Mesoporous silica nanoparticles have recently attracted researchersпїЅ attention by opening a new perspective on the development of new drug delivery systems. Such mesoporous materials are characterized by a uniform distribution of pore size, welldefined walls with a high volume that enables functionalization at the level of silanol group, having a large specific surface and good hydrothermal stability. The objective of this study is the synthesis and characterization of MCM -48 and KIT-6 silicate matrices, biomat...

The present research is a part of the obtaining innovative medicine domain and is concerned with conceiving and developing new anti depressive medicines, endowed with a high therapeutically degree, low secondary effects and impact on the quality of life, through a research partnership. The impact of Borderline personality disorder (BPD) diseases, especially depression, is continuously growing and as a treatment, are used anorganic products based on lithium, such as lithium carbonate, lithium citrate or lithium oro...

The goal of the present study is to evaluate the use of mesoporous silicate nanoparticles MCM-41 for the loading and release of the magnolol. MCM-41 has a hexagonal arrangement of mesopores, with diameters ranging from 2 to 10 nm. The homogeneity of the cylindrical pores, high surface area with uniform porosity, and good thermal stability, which make them an attractive molecular sieve for applications in sorption of large organic molecules, as well as host for quantum confinement of guest molecules. Also, the bioc...

The objective of the study was to increase the solubility of amiodarone hydrochloride by complexation with hydroxypropyl-пїЅ-cyclodextrin. After complexation a cyclodextrin/amiodarone inclusion complex was formed. The use of media containing surfactants is a suitable solubilizing method and as a result, a non-ionic surfactant - Tween 80 and an anionic one - sodium lauryl sulfate have been used. The dissolution profile of amiodarone hydrochloride and that of the inclusion complex, regarding the release of the activ...