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Organs-on-chip allow for establishment of physiologically relevant models of human tissues and organs, and specifically of blood-brain barrier (BBB) and neurovascular unit (NVU) in their normal or pathological state. BBB/NVU integrity and functions are compromised in course of different diseases or injuries, like traumatic brain injury, stroke, multiple sclerosis, arteriovenous malformations, vascular dementia, Alzheimer?s disease, atherosclerosis, brain cancer, inflammation, genetic disorders, and many more. In t...

The thickness of the blood-brain barrier (BBB) basement membrane (BM) in vivo is in the range of 20 - 200 nm. Most widely used commercially available microporous polycarbonate (PC), polyethylene terephthalate (PET) or polytetrafluoroethylene (PTFE) membranes are 10 to 50 ?m thick. This is a substantial obstacle for communication of cells growing on both sides of membrane, like astrocytes, pericytes and endothelial cells within in vitro BBB model. For the last several years the active development of ultrathin micro...