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Alzheimer?s disease, the most common age-related dementia worldwide, is characterized by two pathologies: deposition of ?-amyloid plaque and neurofibrillary tangles of hyperphosphorylated tau. To this date, several factors, such as oxidative stress, metal ions, or genetic factors are associated with Alzheimer`s diseases, but there are still some question marks regarding: (i) how the misfolding and aggregation of A? occurs and which is the aggregation mechanism; (ii) how the metal ions binds to A? and how they init...

Neurodegenerative diseases are a group of pathologies that mainly affect neurons of the human brain. Particularly, Alzheimer disease (AD) is a neurodegenerative disorder, being manifested by neuronal and synaptic loss. One of the main pathological aspects of AD is aggregation of amyloid-? (A?) peptide. However, there are some neuropeptides that play an important role in immunity and neuroprotection. In addition, the presence of metal ions and their abnormal accumulation play a key role in this pathology. The inter...