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An immunological diagnostic examination of 255 children permanently residing in the zone of influence of exogenous haptens and the intense climate of the Arctic was performed. The control group consisted of 130 children living in the territory beyond the influence of exogenous chemical and climatogeographic factors. Determination of total serum immunoglobulins G, A, M was performed using the Mancini radial immunodiffusion reaction. The concentration of total IgE, neuron-specific enolase and VEGF was determined usi...

The authors have conducted an experiment that involved modeling of interactions between immune regulation mechanisms applying a viral load simulator in vitro. The experiment was performed on a suspension that contained immune cells extracted from peripheral blood samples (68 samples overall). There were several influencing factors such as impacts exerted by managing elements including cytokines (IL-1), hydrocortisone, and exogenous environmental factors represented by aluminum compounds (aluminum oxide) as well as...

Today, the analysis of the unique contribution to the formation of the ?genetic portrait? of regional features, including technogenic ones, which determines the occurrence of diseases and harm to health, is relevant. The use of modern critical genetic and cellular biotechnologies with the study of genetic polymorphism and thin cell subpopulations will allow us to catch the earliest violations of homeostatic indicators in geochemical technogenic provinces. The aim of the work is to assess the features of genetic in...