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The specificity of the microelement environment in the population of individual geochemical provinces determines the features of homeostasis regulation processes. In conditions of excessive intake of strontium with drinking water, it is assumed pathological disorders of the parameters of osteometabolism with the involvement of immune regulation mechanisms. We examined 59 children of preschool age permanently residing in the territory of the strontium geochemical province and consuming drinking water with an excess...

Chemical compounds of natural origin have high biological activity, complex effects on the human body, and safety for health. Preparations based on natural plant raw materials affect the body's adaptive capabilities, acting as factors of nonspecific defense and cofactors of the immune system. The aim of the study is to evaluate the effect of phenolic constituents of plant origin on the phagocytic activity of peripheral blood cells in vitro. Materials and methods. In vitro study of the effect of phenolic constituen...

A high level of professionally determined morbidity conditiones the need to identify marker indicators of health status, immune adaptation mechanisms and markers of sensitization under conditions of exposure to harmful production factors. We examined 70 employees of the sylvinite processing plant, workers in unfavorable conditions of chemical exposure to dust of potassium chloride, saturated hydrocarbons (hexane), formaldehyde. The comparison group consisted of employees of the administrative apparatus. The formal...

Considering the high potential threat to the environment and humans caused by the components of dust and gas emissions, the aluminum industry belongs to the category of industries of increased danger to public health. Violation of the process of apoptosis control under the negative influence of environmental factors leads to homeostasis shifts and is one of the many factors contributing to the development of immune regulation disorders. This paper aims to assess the features of cell death in the adult population o...

Excess natural and technogenic chemical exposure have a negative impacts on the regulatory systems of the body. This leads to a decrease in its resistance and adaptabilities. The child`s body is the most vulnerable to the impact of adverse environmental factors owing to the age characteristics. Strontium belongs to the group of metals that can form an improper quality of drinking water, and is also included in the list of the main indicators of water quality according to the requirements of sanitary standards of t...

An immunological diagnostic examination of 255 children permanently residing in the zone of influence of exogenous haptens and the intense climate of the Arctic was performed. The control group consisted of 130 children living in the territory beyond the influence of exogenous chemical and climatogeographic factors. Determination of total serum immunoglobulins G, A, M was performed using the Mancini radial immunodiffusion reaction. The concentration of total IgE, neuron-specific enolase and VEGF was determined usi...

Summary. Aluminum, entering the human body, has the property of accumulation, modulates immunoregulation and metabolism, especially mineral. It also exhibits the properties of a sensitizer and neurotoxicant, mutagen and carcinogen. And in the case of aerogenic exposure, the target object is additionally the upper and lower respiratory tract system. Exposed by aluminium children are especially inclined to occurrence of negative effects. The research is aimed to study the immune status of children of primary school ...

Anthropogenic factors of the production environment of oil production are characterized by more intensive influence of these factors in contrast to the external environment, which can create the prerequisites for early development of adaptation disorders, functional changes in immune and humoral regulation, especially with their genetic determinism, and the formation of an increased risk of development and weighting of cardiovascular pathology in those engaged in oil production. The aim of the work was to study th...

Introduction Violations of autonomic nervous regulation are a multifactorial pathology, while environmental features are an important risk factor for this pathology. Excessive exposure to neurotropic technogenic chemical factors, including benzene, to the biological environment of the human body induces malfunctions of adaptive-compensatory mechanisms and forms an increased risk of developing disorders of autonomic regulation associated with the immune system, which are realized against the background of polymorph...

Introduction. The Eastern region of the European part of Russia (Perms Krai) is characterized by the peculiarities of the wind regime, the presence of large highways and petrochemical enterprises. Aromatic hydrocarbons (AH) are highly prevalent in the environment and are found in emissions from vehicles and industrial plants. These substances belong to hormone-like xenobiotics, which are capable of making adjustments to the work of immune and hormonal regulation. Purpose of the work: analysis of the features and p...

Drinking water contamination with technogenic haptens forms an imbalance in the adaptive capabilities of the immune system in children. The aim of this work is to study the features of laboratory markers of the cytokine profile in children, probabilistically associated with an increased content of chloroform in the blood. Materials and methods. The study involved 283 children living in conditions of chronic low-level oral exposure to hyperchlorination products of drinking water, the control for which was a conting...

Introduction. The extreme nature of environmental meteorological factors and the asynchronous change of day and night are considered to be one of the reasons leading to a decrease in the life quality in the Extreme North. These might lead to a violation of adaptive mechanisms under certain conditions. The combination of variants of polymorphic candidate genes causes functional disorders of the cardiovascular system. The research aims at studying the genetic polymorphism in children having pathologies of the cardio...

The peculiarities of ecological conditions determine different scenarios of adaptive changes in the immune and genetic status with the subsequent formation of eco-caused pathology. Purpose of the study: analysis of the peculiarities of the immunological and genetic status of the child population in the extreme conditions of the Arctic Circle of Russia under the combined impact of anthropogenic chemical and climatogeographic factors. Materials and methods . Immunological and genetic testing of 98 children (the terr...

The authors have conducted an experiment that involved modeling of interactions between immune regulation mechanisms applying a viral load simulator in vitro. The experiment was performed on a suspension that contained immune cells extracted from peripheral blood samples (68 samples overall). There were several influencing factors such as impacts exerted by managing elements including cytokines (IL-1), hydrocortisone, and exogenous environmental factors represented by aluminum compounds (aluminum oxide) as well as...

Today, the analysis of the unique contribution to the formation of the ?genetic portrait? of regional features, including technogenic ones, which determines the occurrence of diseases and harm to health, is relevant. The use of modern critical genetic and cellular biotechnologies with the study of genetic polymorphism and thin cell subpopulations will allow us to catch the earliest violations of homeostatic indicators in geochemical technogenic provinces. The aim of the work is to assess the features of genetic in...

This study aims to assess the influence of anthropogenic chemical factors on the formation of comorbid conditions associated with pancreatic pathology under combined gene polymorphism. The urgency of the problem lies in the disruption of the ecological balance and pathological adaptation of the organism to an excessive level of ecological anthropogenic factors due to compensatory negative shifts in genetic homeostasis. The real-time polymerase chain reaction with allelic discrimination was used to study the polymo...