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An environmentally safe method - metal-vapor synthesis (MVS), was applied to produce iron nanoparticles (Fe NPs), which were conjugated with the drug methotrexate (MTX). The physicochemical properties and biological activity of the generated Fe NPs-MTX nanomaterials were analyzed. Transmission electron microscopy observations indicated that Fe NPs are stabilized in the form of aggregates with a size of 100 nm. The structure of these aggregates is similar to a -bunch of grapes-, which consists of metal particles ab...

Gold and iron nanoparticles were generated via environmentally safe metal-vapor synthesis method applying acetone or toluene as organic dispersion medium. Biological properties of the nanoparticles were analyzed by the agar disc diffusion method using Gram-positive and Gram-negative bacteria and via in vitro cytotoxicity assays with different human cell lines. The obtained results revealed distinct biological activity profiles of the studied specimens. Fe nanoparticles (Fe NPs) demonstrated inhibitory effects agai...

Autoimmune diseases affect approximately 5% of the population worldwide. Generally, these disorders induce high degree of morbidity and disability and therefore, they have a significant social and economic impact. The precise diagnosis of specific autoimmune response is necessary for adequate treatment of the patient. Accordingly, the diagnostic assays for autoimmune diseases are continuously developing and improving. Biofunctionalized nanoparticles represent a promising novel approach in this field. Our group has...

Iron oxide (II, III) nanoparticles (ION) are used in variety of biomedical and industrial applications (for instance, in gene therapy, cell tracking, magnetic resonance imaging, drug delivery therapies, in vitro diagnostic assays, catalytic materials, wastewater treatment adsorbents, nanoadjuvants for vaccine and antibody production, coatings, gas sensors, ion exchangers, magnetic recording devices, magnetic data storage devices). In relation to their vast utilization there is a need for more information on the ef...