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Amiodarone (AMD) is an antiarrhythmic agent used for the treatment of ventricular arrhythmias, arterial fibrillation, and severe rhythm disorders. The main therapeutic disadvantage of AMD is its low oral bioavailability and low water solubility. The aim of the study was to obtain the hydroxylpropyl-?-cyclodextrin/AMD inclusion complex and to assess its degree of drug loading using a new HPLC method. The solubilizing effect of cyclodextrin on AMD was evaluated by the phase solubility method. The concentration of AM...

The paper presents the results of theoretical and practical research on developing the infrastructure for assessment of overall risk (explosion / occupational terrorist attack) associated with unwanted events such as major accidents that can occur at explosive storehouses for civilian use. The scientific research outlined in this article was carried out within the NUCLEU Project PN 16 43 02 15 - ?Research on increasing safety levels at technical facilities for storage of explosives for civil use?. The key element ...

When thinking about sustainable design, social sustainability appears to be a fundamental feature that must be considered when shaping people and communities. This broad subject is narrowly approached within the present article following one specific viewpoint; social sustainability can be defined in the design process by analyzing materials? potential in crafts` and industries` activities alike. Paper`s potential on both these levels, in developing, through its production process, small scale communities and larg...

The technology of Permeable Reactive Barriers in recent years is one of the most frequently developed methods of protecting the soil and water environment from pollution. These are zones filled with reactive material, in which during the flow of contaminated groundwater, contaminants are immobilized and/or their concentration is reduced to the limit values. Currently, there are relatively few deep installations compared to shallow systems (e.g. <10 m), resulting mainly from higher costs and technical difficulties ...

The development of measures to improve the transport networks of cities require studying the patterns of changes in their main parameters of traffic flows after the implementation of these activities. Investments in urban transportation networks should base on accurate methods of assessing the changes in the social-economic and ecological performance of transportation networks, due to the factors affecting them. The development of such methods is possible basing on patterns of changes in the characteristics of roa...

Technologies based on photogrammetric and remote sensing sensors represent the usual way for obtaining digital height and position data. This paper is dedicated to LiDAR data filtering for a DEM generation. The main purpose is presentation of a semi-automated method of filtering using mathematical and statistical algorithms for a valid data set. The method involves point cloud data filtering and interpolation. The principle of it is to validate an error free data set and construct the DSM from the last pulse refle...

In this paper we used the research done in a previous laboratory study in which we optimized the addition of seabuckthorn powder, rosehip powder and grape seed extract to the classic yogurt formulation. Yogurt with the best physicochemical and sensory properties was obtained by adding 1.5% rosehip powder and 0.5% grape seed extract, respectively 1.75% seabuckthorn powder and 0.25% grape seed extract to its manufacturing formulation. Prior to inoculation, the ingredients mixture was pasteurized at 85В°C for 30 minu...

In this paper we used the research done in a previous laboratory study in which we optimized the addition of seabuckthorn powder, rosehip powder and grape seed extract to the classic yogurt formulation. Yogurt with the best physicochemical and sensory properties was obtained by adding 1.5% rosehip powder and 0.5% grape seed extract, respectively 1.75% seabuckthorn powder and 0.25% grape seed extract to its manufacturing formulation. Prior to inoculation, the ingredients mixture was pasteurized at 85В°C for 30 minu...

In this paper, combined effects of carbon fibres treatment and compatibilizer polymers (PE-g-MA) on the structure and properties of PA/PE/PE-g-MA/ functionalized carbon fibres composites were studied. The optimum formulation was used to prepare a series of nanocomposites under different technological conditions. Also, a correlation between their physico-mechanical properties and IR spectra (ATR technique) was proposed. The carbon fibres functionalisation consisted in oxidizing the nanoparticles with oxidant mixtur...

The planned maintenance activities of the mining technological equipment are carried out on the principles of risk management and is done in order to prolong their duration of operation and to reduce the production cost. The quick possibilities of reducing production losses due to accidental stoppages of quarries and underground exploitation equipment, depend on the establishment and application of reconditioning methods of the subassemblies and spare parts that are frequently defects and replacement. The rotary a...

The concept of a ?passive House? has been introduced for the first time in Germany, subsequently being extended and at higher latitudes and different features climatic from those of Germany, in the south, west and south-west of Europe. Passive building has been defined by Wolfgang Feist, Passivhaus Institut, as being the building that demand for heating must not be more than 15 kWh/m? year, and total consumption of primary energy should not be more than 120 kWh/m? year. In this paper we strive to study at the conc...

For produce electricity from solar energy, it would be necessary for an inverter to convert the continuu current (DC) into alternating current (AC). The inverter is the cause of problems affecting the stability of the power supply system because it is a switching device used to adjust the AC frequency as required. At the same time, it can cause harmonics that result in waveform distortions and affect electronic devices that receive energy. Then it could cause malfunction of the electronic device. In this paper, we...

In the present paper, we present a part of the results of the questionnaire survey, which took place in the municipalities of 93 municipalities in the Presov region. The questionnaire contained 27 questions which, in addition to formal information on the municipality are focused on the occurrence and periodicity of floods, the time axis of the floods, the current state of preparedness of municipalities for floods, as well as the improvement/ worsening of the situation in the case of applied flood protection measur...

The recovery factor of gas reservoirs is highly dependent on various factors such as the type of drive mechanism, the initial reservoir pressure and the abandonment pressure. A higher attention is required to enhance gas recovery from reservoirs associated with water influx. Exploitation of this type of reservoirs represents a challenge for production operators in the sense that they have to find viable technical and economic solutions in order to increase the gas recovery of reserves. The selection process for th...

In recent years, bio-economics and alternative energy sources have become increasingly important in the economic environment of the European Union. The reasons for this development are not only environmental, but also economic benefits. The Union is seeking to increase investment in alternative energy sources, thereby promoting sustainable development, new jobs and the circular economy. Alternative energy sources, also known as renewable energy are inexhaustible sources of energy that do not pollute the environmen...

Background: The role of reporting on non-financial data and Corporate Social Responsibility (CSR) is constantly growing. Environmental information is of great importance for this information. There are no proposals for methods of obtaining this information using the existing accounting information system. For this purpose, the author proposes to use the pro-ecological value chain, which then can be a good ?base? in generating management environmental reports. Methods: The author used literature analysis in the fie...

To improve the technology of opening and development of oil fields for increasing the completeness of subsoil use, the prospects of using the electric pulse method of drilling are discussed. Validated the concept of creating an electric pulse tunnel system based on submersible source of high-voltage pulses with controllable formation of work space for increasing its maneuverability and creating special technological outputs in a rock mass for forming a cluster of slant and horizontal boreholes with most complete c...

The rocks exploited in quarries have certain physical, mechanical and technological characteristics that favors the intense wear, especially by abrasion of the active surfaces of the subassemblies of the technological equipment. Some spare parts and subassemblies are subject to similar wear phenomena, as is the case with the excavators bucket teeth in the lignite pits and the loaders cup teeth in the basalt pits. In the case of the basalt aggregates which are the main raw material needed for the development of the...

The temperature at the Earth?s surface can be estimated by ground-based methods or satellite remote sensing data. Satellite remote sensing is the only means of obtaining longterm homogeneous series of land surface temperature data. The network of ground-based observations usually is quite rare, so it is important to obtain information by remote methods. From the values of the thermal infrared spectral bands, it is possible to determine the radio brightness temperature of the underlying surface. The compilation of ...

Magnetic nanoparticles (MNPs) of iron oxides are increasingly used in many laboratory and medical applications such as hyperthermia, magnetic resonance imaging or magnetic drug delivery. Popular in medical applications are magnetite (Fe3O4) and maghenite (?-Fe2O3) nanoparticles. They have gained a great interest because of their low toxicity, biocompatibility, simple separation methodology, and low cost of production. A novel magnetic hydrogel adsorbent based on gellan gum and Fe3O4 (GG/Fe3O4) was synthesized and ...

The effects of global warming are becoming more and more felt by changing climatic conditions across the entire surface of the earth. Thus, in some regions of the Earth's surface, catastrophic floods have begun to occur more and more often due to the increase in both the occurrence frequency and the intensity of torrential rains. In order to reduce the flood damage, it is necessary to prepare hazard maps and flood risk maps. These maps are prepared using hydraulic simulation of the flood propagation on the waterco...

Research institutions and academia play an important role in developing new methods for disaster management and advancing the state-of-the art in risk reduction. In the case of natural disaster studies, fundamental research and theoretical approaches can be directed towards the development of new tools and technologies with direct applicability in the management of emergency situations and in risk mitigation. What needs to be considered by all those actors who can contribute to strengthening the response capacity ...

Under intense stress, energy consumption undergoes essential changes that largely depend on functional characteristics of the respiratory system, which in turn are in close correlation with the body?s training degree and physical demand. During a pronounced dynamic effort, there is a progressive decrease in blood oxygen saturation and an increase of pulse. Cardiac rhythm is a physiological parameter commonly used in telemonitoring as it allows the assessment of rescuer?s general condition, heart rhythm disorders b...

In the combustion processes the nature and concentration of the developed gaseous effluents depends on the type of materials that are subject to combustion as well as on the conditions in which the oxidation processes take place. The purpose of this paper is the experimental determination of the combustion parameters and the study of the developed gaseous effluents from several combustible materials. The production of gaseous products resulting from combustion results in different yields depending on several param...

This paper presents the research undertaken in order to establish a processing technology for the Budureasa dolomitic limestone. For this, a series of physico-chemical and mineralogical analyzes were performed, but also unitary processing operations such as grinding, calcination, gravitational concentration and flotation, and solubilization with carbon dioxide in an aqueous medium to obtain a MgO ? rich concentrate, usable in various fields of activity, under economic efficiency conditions. Mineralogical, chemical...

The study aims to present the interspecific relationships between fish and cormorants from Comana Pond and Putu-Greci ponds. Also, it is presented the dynamic of the ichtyofauna, during 2011-2017 years, in Comana Nature Park, on the watercourses of the Neajlov River, Comana Pond or Neajlov Delta, Gurbanu River and Putu-Greci Ponds. The Comana Pond, with area of 1200 hectares, in 2011 suffered a major intervention on the habitat characteristic of wetland, namely an ecological reconstruction, by constructing a low-r...

The decisive factor in the process of under pressure networks inspection is determined by the correct choice of the control method in order to observe with great attention the possible faults caused by the physical wear and tear resulting from the long use. Emphasis is placed on safety conditions of under pressure equipment, which include mandatory minimum technical requirements for periodic checking of under pressure networks for pressurized, liquefied or dissolved gas. Defectoscopy is a set of procedures used to...

Surface geochemical method is an important technique in petroleum exploration. The purpose of this method is to record and analyze the distribution of micro-concentration of gaseous hydrocarbons, which migrate from subsurface accumulations to the near-surface zone. The paper presents the results of surface geochemical survey carried out in the area of the Mo?odycz gas deposit of the Carpathian Foredeep. A soil-gas geochemical survey was carried out along the six sampling lines corresponding to the seismic section....

Nowadays, traditional residential houses are not built anymore, with few exceptions, although they represent valuable assets from the heritage point of view and also an important part in our cultural identity. In addition, they can be regarded as a seismically resilient typology and also as a cheap construction due to the use of local materials and especially of self-workmanship. The construction details of traditional houses used to be done very carefully, but this habit got lost with time. In recent years, due t...

Protecting human labors process seeks to eliminate and/or reduce the potential causes of injury and disease in order to achieve full control of risks from hazards associated. With all the technical progress and technology in most industries, and especially in the oil and natural gas, there are failures with casualty and property damage. For this reason, it is indispensable the presence of the special intervention and rescue teams to limit/ liquidation, failure that generates explosive atmosphere and/or toxic and r...

This year, for the first time in Latvia, the government will adopt a set of standards that will regulate social entrepreneurship and its goals. Social entrepreneurship means balancing social goals and the commercial component for which money is not the direct goal but rather a means of achieving social goals. The social aspect should not only target the surrounding community, but also ensure responsible and correct treatment of employees. A leader in a social enterprise has to put an end to the controlling style o...

The main purpose of this study is to highlight the actual state of energy production and consumption in Romania and to emphasize where there is potential for either reducing the greenhouse gas emissions by using more efficient heating and cooling systems for buildings or reducing the greenhouse gas emissions by using less fossil fuels and more renewable energy sources that can be tapped in Romania. In Romania despite a good thermal insulation degree for newly constructed buildings in the past 5-10 years there is s...

Since ancient times, the coastal areas were natural habitats that host a wide variety of fauna and flora species and which, from an anthropological point of view, are the most populated areas of the planet. At the same time, these areas, which include deltas, lagoons and marshlands, are particularly vulnerable to the effects of global change (climate modification, sea level rise and fluctuation of sediment input) that may be triggered by anthropogenic activities (global warming due to greenhouse gases produced dur...

Environmental monitoring systems in the cities existing in modern cities allow to control the state of natural (technogenic-natural) systems according to their programs. But it is not possible to receive an information for some special locations despite their significance ? this is a case of the RUDN-University campus. For these purposes an initiative group organized a special monitoring project for the campus. One part of these monitoring program is a control of the soil air quality. This is a one of the most rep...

Soil pollution with heavy metals is a major global environmental problem for many ecosystems. The exploitation and processing of non-ferrous ores are one of the most important anthropogenic sources of soils contamination with heavy metals. Romania is a rich country in mineral resources, therefore it has a long history of their exploitation. In this regard, there are several areas for the non-ferrous ores extraction, and one of them is located in the Metaliferi Mountains, where the tradition in gold, silver and oth...

Authors describe the novel approach to boost the scientific data analysis performance with the data-storing schema for distributed scientific research systems. This approach optimizes the workload on storage nodes and enhances the computation performance. Managing the enormous output of scientific research systems is expected to be the most technically difficult part of all recent projects producing Petabytes of imagery data. In this paper we describe the distributed storage structure with indexing techniques whic...

?Dimensioning all the elements in the urban layout should not be executed in any other way but that which is in accordance with human scale? [1], [2]. Evolution of the development of towns and cities resulted in the development of various models of spatial layout and the relations between urban units and human beings. Ancient and medieval towns demonstrated compact spatial arrangement, which resulted in generating shorter journeys and provision of security for the inhabitants. However, the very dense network of st...

Actual tasks in development, configuration, utilisation and support of complex technical, economic and natural systems require a deep understanding of its internal processes. System dynamics discipline is devoted to that problem and let to researching and analysis the complex systems behaviour. The base of it is a numerical method for dynamic system modelling. Modelling processes for real systems require significant computational resources (time and power consumption). Authors provide the approach to the optimisat...

We deal with the target of our work that is to provide a general overview of the Slovak scene relating to the Startups. Our aim is to analyze the area of innovative entrepreneurship and start-ups in individual sectors of the Slovak economy (mining industry, renewable energy sources, tourism, etc.). It is necessary to state the reasons that lead to the development of startups and to analyze their impact on the economy of the national economy in terms of creating new jobs. We have explored successful and less succes...

The main objective of this paper was to assess the water quality in Siret, in the Galati area. Galati is a port town on the Danube River in south-eastern of Romania. For the purpose of carrying out these studies, water samples from ten Siret sites were taken. Water quality has been monitored between November 2016 and December 2017. Physical and chemical characteristics of water were performed. The PFP7 Flam Photometer was used for potassium and calcium ions determination. An UV-VIS Specord 210 Spectrophotometer wa...

The paper presents the impact of variable environment acidity and low temperature on the stability of biosensor receptor layer component BSA (Bovine Serum Albumin). With the use of UV/Vis spectrophotometer, absorption spectra in range (250-300nm) was taken to study conformational changes of the protein with time after exposition to different factors. The results showed an increase in absorption, associated with the conformational changes of BSA with time. A significant decrease in the absorption intensity was note...

The paper presents the impact of variable environment acidity and low temperature on the stability of biosensor receptor layer component BSA (Bovine Serum Albumin). With the use of UV/Vis spectrophotometer, absorption spectra in range (250-300nm) was taken to study conformational changes of the protein with time after exposition to different factors. The results showed an increase in absorption, associated with the conformational changes of BSA with time. A significant decrease in the absorption intensity was note...

In industrial plants many types of combustible dusts are generated, processed, handled and stored. When ignited, they can burn rapidly and with a considerable explosion force, when mixed with air in proper proportions. This is the reason why adequate precautions have to be adopted, to ensure that all equipment and protective systems are appropriately protected so that the security level from these installations to be high. The establishment and implementation of protection measures is primarily aimed at preventing...

The application of reactive materials in the form of a Deep Permeable Reactive Barrier during and after coal conversion constitutes an innovative concept of protecting the environment from georeactor influence. The reactive materials filling the post-process cavern will make it possible to remove or immobilise the gaseous and liquid contaminants that may be subject to leaching, while also reinforcing rock mass stability. The article pays particular attention to the technical and legal possibilities for reactive ma...

Sintioana, the component of the Sinmartin commune, Cluj County, it was necessary to execute operations at legal, economical and technical level. This operation was done successively on cadastral sectors. The present paper deals with the study of the technical operations necessary for the introduction of the real estate cadastre, as well as the achievement of the site and delimitation plans for each building in part, from four cadastral sectors of within the built-up area of Sintioana. In order to take over the tec...

The production of agricultural products in Russia is associated with complex natural and climatic conditions. Today up to 80% of the lands need irrigation. Therefore, the expansion of irrigated areas, improving the quality of their conditions, improving of the irrigation technologies and increasing of the production from the irrigated lands will allow not only to meet the needs of the country's population in agricultural products, but also to increase export of the country, to create of new jobs for the country po...

Nowadays, raised awareness about the importance of sustainability and also the environmental impact of using concrete in the construction industry has led to numerous studies on how to create an environmental friendly material, with self-cleaning properties and how to possibly use it in urban areas and to ensure a cleaner environment and reduce maintenance costs. Nitrogen oxide (NOx) is the air pollutant which is directly responsible for the air pollution due to smog, smoke, vehicle emission, etc. The self cleanin...

According to the Aridity Index (R), at the level of the Eastern Romanian Plain have been identified certain areas of aridity intensity, differentiated from the West to the East as a result of the degree of continentalism increasing, which also led to a specific geobotanic zoning (the forest area, the interference between the forest-steppe, ante-steppe and steppe). The degree of vegetation coverage is an objective indicator of susceptibility of soil and/or land to degradation processes, which are manifested on larg...

The purpose of this paper is to present traditional building concepts from the local seismic culture, with a seismically resilient typology: from timber structures to framed wall structures, timber frame structure with infilling materials etc. The structural shortcomings of masonry structural systems with one or two storey, which were observed at the incidence of intermediate Vrancea earthquake from the past, will be emphasized: some architectural and constructive elements that impose a good/poor behavior and type...

The research analyses and evaluates changes of dendrometric indices of Scots pine (Pinus sylvestris L.) young growths over years, characterizes the impact of various factors on growth course. The investigation includes data of 84 sample plots arranged in western, central and eastern regions of Latvia. The established sample plots comprise forest compartments in Vacciniosa, Myrtillosa, Hylocomiosa, Vacciniosa mel. and Myrtillosa mel. site types. The data obtained in sample plots were collected in period between 201...